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Therapeutic pipeline
VAS203
VAS203 is an allosteric NO synthase inhibitor which interacts with the BH4 binding site (cofactor tetrahydrobiopterin) of the enzyme. It is the first drug targeting both brain vasculature and parenchyma and therefore represents a completely novel and unique pharmacological approach for the treatment of traumatic brain injury. vasopharm will enter clinical trials by the end of 2006. VAS203 is covered by a number international patents owned by vasopharm providing exclusivity until at least 2022. Patents cover both target and composition of matter.
VAS2870
VAS2870 is a NAD(P)H oxidase (NOX) modulator identified for the treatment of peripheral arterial occlusive diseases (PAOD). VAS2870 is one of several NOX modulators under evaluation at vasopharm. Compounds of this class – which are able to increase biologically available NO in progressive and chronic diseases – have potential in the treatment of the underlying causes of several cardiovascular diseases.
